Snorting chemicals has a bad rap. But as a method of drug delivery, it may be on the verge of a renaissance. Unlike medications taken orally, intravenously or otherwise, those sniffed up the nose gain direct access to the brain. Recent findings that intranasal administration is indeed safe and effective--and a revamped delivery system more elegant than a rolled-up twenty--have inspired a new appreciation of the sniff. Below we list a few of the drugs that researchers are experimenting with, including molecules of new shapes and sizes as well as novel uses of medications developed decades ago.