Variations in an enzyme belonging to the immune system that leaves individuals susceptible to Ankylosing Spondylitis have been identified by researchers. The variation in ERAP1 can be detected by genetic testing which, if available, could lead to people becoming aware of the risk of the condition earlier. Ankylosing Spondylitis is a chronic inflammatory disease which mainly affects joints in the spine. In severe cases, it can eventually cause complete fusion and rigidity of the spine, called "Bamboo spine". It tends to first develop in teenagers and young adults with most cases first starting in people aged 20-30.

Source: New insight into risk of Ankylosing Spondylitis